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Rodent model Normalised body composition when combined with a reduced-calorie diet 22-week-old diet-induced obese C57BL/6J mice switched to a lean diet and given daily intraperitoneal NNMT inhibitor for 7 weeks, n = 6 to 8 per group, lost 6.3 g against 2.9 g for the diet switch alone, with a 29.3% reduction in fat mass against 2.9%, and a 6.4% rise in the lean mass to body weight ratio

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